From the North:
Motorway A 61 to the intersection Mutterstadt, then A 65 towards Neustadt/Weinstrasse, exit Deidesheim.
On the motorway A 67, drive until the intersection (Autobahnkreuz) Viernheim, then take the A 6 towards Saarbruecken, at the Frankenthaler Kreuz (intersection Frankenthal) go onto the A 61 towards Speyer, at the intersection Mutterstadt (Autobahnkreuz Mutterstadt) take the A 65 toward Neustadt/Weinstrasse, exit Deidesheim.
On the motorway A 5, drive until the intersection Weinheim, then change to the A 659 towards Viernheim, at the intersection Viernheim change onto the A 67 towards Darmstadt, at the Viernheimer Dreieck (motorway junction Viernheim) change on the A 6 towards Saarbruecken, at the Frankenthaler Kreuz onto the A 61 towards Speyer, at the intersection (Autobahnkreuz) Mutterstadt change onto the A 65 towards Neustadt/Weinstrasse, exit Deidesheim.

From the South:
Motorway A 5 until Karlsruher Dreieck (junciton Karlsruhe), then drive on the A 65 towards Landau/Pfalz and Neustadt/Weinstrasse, exit Deidesheim.
Motorway A 5 until Autobahnkreuz Walldorf, then change onto the A 6, at the intersection (Autobahnkreuz) Hockenheim change onto the A 61 towards Speyer/Koblenz, at the Autobahnkreuz Mutterstadt to A 65 towards Neustadt/Weinstrasse, exit Deidesheim.

From the East:
Motorway A 6 until the intersection (Autobahnkreuz) Hockenheim, then change on the A 61 towards Speyer/Koblenz, at the Autobahnkreuz Mutterstadt change to the A 65 towards Neustadt/Weinstrasse, exit Deidesheim.

From the West:
Drive on the motorway A 6 until Frankenthaler Kreuz, then change onto the A 61 towards Speyer, at the intersection (Autobahnkreuz) Mutterstadt change onto the A 65 towards Neustadt/Weinstrasse, exit Deidesheim