From Madrid:
Take the exit 123 (Granada-Almanjáyar-Maracena) from the A-44 (former N-323). Then Carretera de Jaén direction to bus station, which will be in your right hand side. Then   you will see a shopping centre called "Alcampo" in your left,  take  first street in your left "Calle Tete Montoliú", then  second on your right hand side "Avenida de Pulianas", then, when you find the indications: Campus Universitario, Albaizyn, you´ll go up the Avenida de Murcia, just at the end, you have to follow the indications of Albaizyn, through the Carretera de Murcia, keep in the big road, till you find the indications of Acceso a Albaizyn por Calle Pages: You will get to Calle Pagés. (You might find this road blocked by pillars. That’s because access to the Old Town (Albayzín) is limited at certain times of day. In this case, press the button and say the hotel name and your reservation number. If the street is not blocked you don’t have to stop.) Having passed the pillars keep going on the main street till you get to a church (El Salvador). Go around it and head on. Take  first street on your right. After a pharmacy, about 50 metres ahead is the parking lot. Stop here and fetch the garage keys from the hotel reception at Santa Isabel La Real, which is right behind the parking lot.

From Malaga, Seville, Cordoba, Levante:
From A-92 change to A-44 (former N-323) at exit 241-A (Granada).
Go on as described above.